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Oral Diseases and Disorders Research

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This federal aid program is managed by:

National Institutes of Health, Department of Health and Human Services

Objectives:

To improve oral, dental and craniofacial health through research, research training, and the dissemination of health information. The research portfolio supports basic, clinical and transitional research from molecular biology to patient-oriented and community-based clinical investigations. The Developmental Biology and Genetics Program supports research on etiology, pathogenesis, epidemiology, prevention, diagnosis, and treatment of inherited craniofacial-oral-dental diseases and disorders (e.g., ectodermal dysplasia, cleft lip and palate, amelogenesis imperfecta, dentionogenesis imperfecta, osteogenesis imperfecta, and other inherited diseases that have craniofacial-oral-dental manifestations) as well as on normal craniofacial-oral-dental development, and genome-wide association studies. 2. The Translational Genetics and Genomics program supports genetic/genomic research using epidemiologic and family-based methods, gene discovery using high throughput technologies, and gene-enivronment interactions. 3. The Microbiology Program supports basic and translational research on the role of oral microbes in health and disease including the etiology, pathogenesis, diagnosis, treatment, and prevention of oral infectious diseases. Areas of interest include biofilms and microbial ecology, microbial genomics and metagenomics, microbial virulence and disease pathogenesis, prevention and treatment. 4. The AIDS and Immunosuppression Program supports basic, translational and clinical research on HIV infection and AIDS to advance understanding of the underlying molecular, cellular, and genetic mechanisms that enable or prevent HIV infection and development of oral complications associated with AIDS and AIDS malignancies. 5. The Immunology and Immunotherapy Program supports basic and translational research on the immune aspects of oral diseases such as caries and periodontal diseases. The program includes host responses to microbes, immunology of biofilms, oral inflammation, systemic diseases, immunotherapy, immunopathologies, and host susceptibility to infection. 6. The Epithelial Cell Regulation and Transformation Program supports supports basic and translational research on the molecular mechanisms of oral epithelial cell regulation as they relate to the development and progression of diseases of the oral mucosa, including head and neck cancer. The program also supports and encourages the application of genomic, proteomic, and imaging technologies through research on the early diagnosis, prevention, and treatment of head and neck cancers. 7. The Mineralized Tissue and Salivary Gland Physiology Program supports basic and translational research on craniofacial skeletal biology and pathobiology including the physiology of tooth, bone and cartilage, and associated disorders and diseases, saliva and salivary glands, and pharmacogenetics. The goal of the program is to promote interdisciplinary and multidisciplinary approaches to advance the understanding of normal and abnormal processes underlying oral, dental and craniofacial diseases and disorders. 8. The Molecular and Cellular Neuroscience Program supports supports basic and translational research on orofacial pain and neuropathies, temporomandibular joint and muscle disorders, development of biomarkers for diagnostics and prognostics and development of therapeutics. 9. The Tissue Engineering and Dental and Craniofacial Rengenerative Medicine Program supports basic and translational research on the reconstruction, remodeling and repair of the oral and craniofacial tissues damaged as a result of disease or injury. The goal of this scientific program is to promote interdisciplinary and multidisciplinary approaches to engineering of biocompatible oral and craniofacial tissue constructs and their functional integration into the host tissue microenvironment. The program also supports efforts that employ bioengineering approaches for restoration, remodeling and regeneration of diseased and injured native host tissues. 10. The Dental and Biomaterials Program supports basic and translational extramural research on dental materials and devices, dental implants, biocompatibility of dental restorative materials, and biomaterials for craniofacial reconstruction. 11. The Behavioral and Social Sciences Research Program supports basic and applied BSS research to promote oral health, to prevent oral diseases and related disabilities, and to improve management of craniofacial conditions, disorders and injury. 11. The Center for Clinical Research supports clinical trials, dental practice based research networks, epidemiology research, and health disparities research. The Research Training and Career Development Program insures the future of dental and craniofacial research by developing an outstanding and diverse scientific work force through training and fellowship programs designed primarily for graduate, and post-doctoral stages of education, including dual degree (DDS, PhD) programs, as well as for continued career development of scientists and retraining of mid-career scientists. Diversity fellowships serve to expand the diversity of the scientific work force by supporting the training of predoctoral students from underrepresented groups. The Small Business Innovation Research (SBIR) program seeks to increase private sector commercialization of innovations derived from Federal research and development; to increase small business participation in Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. The Small Business Technology Transfer (STTR)STTR program seeks to stimulate and foster scientific and technological innovation and foster technology transfer through cooperative research and development carried out between small business concerns and research institutions; to increase private sector commercialization of innovations derived from Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation.

Funding obligations:

(Salaries) FY 09 $287,349,000; FY 10 est $296,110,000; FY 11 est $298,905,000

Uses and Use Restrictions:

Research Grants: Research Grants provide funds for salaries, equipment, supplies, travel, and other expenses associated with scientific investigation in the oral health sciences. They are awarded to universities, colleges, medical and dental schools, hospitals, and other nonprofit and for-profit institutions. Awards include investigator-initiated project grants, exploratory and developmental grants, small grants, program project grants, center grants, and career development awards. Individual and institutional Dentist Scientist Awards provide support for research career development in both clinical and basic science areas. National Research Service Awards (NRSAs) provide support directly to individuals for research training in specified biomedical areas, and can be made to institutions to enable them to accept individuals for research training. Individuals who receive NRSAs may be obligated upon termination of the award to comply with service and payback provisions. SBIR Phase I grants (duration of approximately 6 months) provide support to establish the technical merit and feasibility of a proposed research effort that may lead to a commercial product or process. Phase II grants support the continuation of the research initiated in Phase I to further develop the commercial products or process initiated in Phase I. Only Phase I awardees are eligible to receive Phase II support. STTR Phase I grants (duration of typically 1 year) support cooperative efforts between small businesses and research institutes to determine the scientific and technical merit, and commercial feasibility of a product or process with potential for commercial application. Phase II funding is based on the results of the research initiated in Phase I and the scientific and technical merit, and commercial potential of the Phase II application.

Examples of Funded Projects:

Fiscal Year 2010: No Current Data Available Fiscal Year 2011: No data currently available. Fiscal Year 2012: No Current Data Available

Program Accomplishments:

Fiscal Year 2010: No Current Data Available Fiscal Year 2011: 154 competing research project grants at $60,822,000. 450 non-competing research project grants at $194,960,000, 29 SBIR/STTR awards at $9,100,000, 6 research centers at $15,876,000, 71 career development awards at $8,835,000, 350 NRSA awards at $17,137,ooo, 14 rants at $1,275,000 other research. Fiscal Year 2012: No Current Data Available

Types of Assistance:

PROJECT GRANTS

Range and Average of Financial Assistance:

FY2008: research project grants: range $9,000-$3,221,000, average $356,000; NRSA: range $18,000-$859,000, average $44,000; SBIR/STTR: range $18,000-$1,861,000, average $381,000. Career development: range $84,000-$181,000, average $109,000. FY2009: research project grants: range $6,000-$3,268,000, average $396,000; NRSA: range $10,000-$1,041,000, average $45,000; SBIR/STTR: range $97,000-$1,328,000, average $301,000. Career development: range $85,000-$181,000, average $122,000.

Length and Time Phasing of Assistance:

Grants: Approval of a project includes a determination of support for the authorized project period (generally not to exceed 5 years). Awards to support the project are made on an annual basis. At the time of initial award, the grant provides funds for the conduct of the project during the first budget period (usually 12 months) and the Notice of Grant Award (Form PHS-1533) indicates the support recommended and expected to be made available for the remainder of the project beyond the approved project period, an application for renewal must be submitted in accordance with the deadline dates and instructions attached to the form. SBIR Phase I awards are generally for 6 months; Phase II awards normally are for 2 years. STTR Phase I awards are generally for 1 year; Phase II awards are for 2 years. See the following for information on how assistance is awarded/released: Awards are made annually.

Applicant Eligibility:

Grants: Scientists at universities, medical and dental schools, hospitals, laboratories, and other public or private nonprofit and for-profit institutions. NRSA and career development awards: (1) Nonprofit domestic organizations may apply for institutional awards. (2) Individual candidates or applicants must arrange sponsorship by a public or nonprofit private institution having staff and facilities appropriate to the proposed research training program. (3) All awardees must be citizens, or non-citizen nationals of the United States or have been admitted to the United States for permanent residence. (4) To be eligible, postdoctoral NRSA and career development awardees must have a professional or scientific degree (M.D., Ph.D., D.D.S., D.V.M., Sc.D., D.Eng., or equivalent domestic or foreign degree). Institutional applicants must be able to provide the staff and facilities suitable for the proposed research training. SBIR and STTR grants can be awarded only to domestic small businesses (entities that are independently owned and operated for profit, are not dominant in the field in which research is proposed and have no more than 500 employees). Primary employment (more than one-half time) of the principal investigator must be with the small business at the time of award and during the conduct of the proposed project for SBIR awards. For STTR awards, the small business must 'partner' with a research institution in a cooperative research and development project where at least 40 percent of the project is to be performed by the small business and at least 30 percent by the research institution. In both Phase I and Phase II for both SBIR and STTR, the research must be performed in the U.S. and its possessions. To be eligible for funding grant applications must be evaluated for scientific merit and program relevance by a peer scientific review group and a national advisory council.

Beneficiary Eligibility:

Any nonprofit or for-profit organization, company or institution engaged in biomedical research.

Award Procedure:

Grants: All accepted applications competing for research project grants, career development awards, and NSRA awards are reviewed by two advisory groups. Primary review is conducted by an initial review group composed of peer scientists, and secondary review by a national advisory council such as the National Advisory Dental and Craniofacial Research Council. Secondary review of NRSA fellowship applications is conducted by the institute staff rather than by the advisory council. All accepted SBIR/STTR applications are evaluated for scientific and technical merit by an appropriate initial review group and by an advisory council. All applications receiving a priority score compete for available SBIR/STTR set-aside funds on the basis of scientific and technical merit and commercial potential of the proposed research, program relevance, and program balance among the areas of research.

Contact Info for Headquarters Office:

Dr. Alicia Dombroski, 6701 Democracy Blvd.; Room 660, MSC 4878 , Bethesda, Maryland 20892 Email: adombroski@nidcr.nih.gov Phone: (301) 594-4805 Fax: (301) 480-8303.

Website Address:

http://www.hhs.gov; http://www.nidcr.nih.gov

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